Doppler Estimation of Reduced Coronary Flow Reserve in Mice with Pressure Overload Cardiac Hypertrophy
نویسندگان
چکیده
منابع مشابه
Direct monitoring pressure overload predicts cardiac hypertrophy in mice.
Pressure overload (POL) is a classical model for studying cardiac hypertrophy, but there has been no direct measure of hemodynamics in a conscious ambulatory mouse model of POL. We used abdominal aortic constriction to produce POL and radiotelemetry to measure the blood pressure and heart rate for three weeks. The cardiac size correlated with the systolic pressure in the last week is better tha...
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OBJECTIVE We have previously demonstrated that nuclear factor kappa B (NFkappaB) activation is needed for the development of cardiac hypertrophy in vivo. NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertrophy in vivo. METHODS TLR4-deficient mice (C.C3H-Tlr4(lps-d), n = 6), wild-...
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Transthoracic Doppler echocardiography (TTDE) is a clinically useful, noninvasive tool for studying coronary artery flow velocity and coronary flow reserve (CFR) in humans. Reduced CFR is accompanied by marked intramyocardial and pericoronary fibrosis and is used as an indication of the severity of dysfunction. This study explores, step-by-step, the real-time changes measured in the coronary fl...
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Increased microtubule density, for which microtubule stabilization is one potential mechanism, causes contractile dysfunction in cardiac hypertrophy. After microtubule assembly, alpha-tubulin undergoes two, likely sequential, time-dependent posttranslational changes: reversible carboxy-terminal detyrosination (Tyr-tubulin left and right arrow Glu-tubulin) and then irreversible deglutamination (...
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Sensing and defeating microbial infections are essential to the survival of metazoan species and contingent upon the reliable detection of pathogens, which are characterized by rapid evolution and molecular heterogeneity. Multicellular species have developed two overall strategies to kill and remove parasites, to send them ‘‘floating on the Stygian river’’ (after the river Styx in Hades, the un...
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ژورنال
عنوان ژورنال: Ultrasound in Medicine & Biology
سال: 2008
ISSN: 0301-5629
DOI: 10.1016/j.ultrasmedbio.2007.11.019